Hi, Thanks for writing in. Multiple sclerosis is diagnosed on MRI scan by a criteria set aside and including clinical symptoms and signs after medical examination. The diagnosis of multiple sclerosis requires establishing disease disseminated in both space and time as per McDonald criteria. Dissemination in space requires ≥1 T2 bright lesions in two or more of the following locations periventricular juxtacortical infratentorial spinal cord Dissemination in time can be established in one of two ways 1. a new lesion when compared to a previous scan (irrespective of timing) T2 bright lesion and/or gadolinium enhancing 2. presence of asymptomatic enhancing lesion and a non-enhancing T2 bright lesion on any one scan. Diagnosis of multiple sclerosis can be confirmed only after fulfilling above criteria on MRI in relation to clinical features.