I have mixed connective tissue disease. I am 44 years old. And weight 205 this morning. I am on leflunomide and prednisone for the MCTD as well as 2 diauretics, elavil, crestor, lisinopril potassium, high dose vit.D and lotab as needed for pain. I had swelling in the soft tissue in the hollows of both shoulders which were negative under MRI. Now the collarbones on both sides hurt and the pain gets worse if I run my fingers over them. The pain radiates into both shoulders. Is this related to the MCTD or is it something I need to get checked out tonight? It started about 6:00 pm my time and has been getting worse.