What Is The Cause Of Inflammation In Neck, Chest And Esophagus? What Does PET Scan Reveal?

Hi. Have you any experience with the following symptoms: muscle and subcutaneous inflammation beginning in the neck, spreading around the entire neck up to the chin, into the chest, constricting the upper esophagus, such that after about 6 months a PET scan of the neck and chest lights up like a Christmas tree. Surgical biopsies of inflamed muscle tissue are consistently crushed during slide preparation precisely because the tissue is so inflamed. Lymph nodes are NOT enlarged and lymphoma has been ruled out twice, both by Lurie Childrens in Chicago and by Mayo in Rochester. No tumor is present. Every other test run by these institutions has come back negative. Within two weeks of each surgical and skin biopsy, the inflammation seems to intensify. What could cause tissue to be so inflamed that Pathology has such a difficult time preparing slides? What would react to surgical intrusion by intensifying itself?