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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Is The Difference Between Orr And Partial Response?

Hi, My dad has been treated twice for mantle cell lymphoma. First time, chemo and autologous stem cell transplant- remission for 8 years. Second time - special chemo for mantle cell- remission for 3 years. He has just been told that it is back again at his six month check up. They are suggesting Imbruvica. In researching this new drug, I don t completely understand some of data in reports. What is the difference between ORR and Partial Response? The percentages don t add up. 65% ORR and 49% Partial response. We are over 100% without even considering the 9% that discontinued treatment. We are just wondering if it is worth the side effects with a median response of 17.5 months. Please help us understand the numbers used in research results a little better. Thank you - Laurie Saslow
Thu, 18 Dec 2014
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Oncologist, Surgical,  's  Response
Firstly, you have to understand that there are 2 types of responses to a drug--complete response (CR) wherein the disease completely disappears, and partial response (PR) wherein the disease decreases substantially but doesnt disappear completely. ORR is short for overall response rate which includes any kind of response (CR or PR). Thus the figure is higher than PR alone. ORR 65% means that out of 100 patients receiving the drug, 65 patients will have some kind of response (CR or PR) while 35 patients will have no response. This is the usual response rate for most chemotherapy drugs and in my opinion you should go ahead with it if you can easily afford and tolerate it.
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What Is The Difference Between Orr And Partial Response?

Firstly, you have to understand that there are 2 types of responses to a drug--complete response (CR) wherein the disease completely disappears, and partial response (PR) wherein the disease decreases substantially but doesnt disappear completely. ORR is short for overall response rate which includes any kind of response (CR or PR). Thus the figure is higher than PR alone. ORR 65% means that out of 100 patients receiving the drug, 65 patients will have some kind of response (CR or PR) while 35 patients will have no response. This is the usual response rate for most chemotherapy drugs and in my opinion you should go ahead with it if you can easily afford and tolerate it.