Hello
You wife is having
TYPHOID fever according to you .
She took oofloxacin 200 mg for 14 days and after 4 days she again got fever and this time she advised
cefixime + ofloacin and fever is not responding and it is around 105 degree F .
Only
paracetamol works but that too for 4 hours .
In my opinion , this type of fever may be due to these reasons, these include:
1
Tuberculosis , diagnosis can be confirmed by C ray chest . Also get in blood for C B C , E S R ( if level is very high i.e. > 100 mm of 1st hours highly suggestive of tuberculosis or any chronic disease.).
2 Typhoid fever , get in Widal and serology test for confirmation.
As you mentioned that your wife is having only fever so get in above mention test .
3
Urinary tract infection may be the another such cause of fever . Get in urine examination .
In my opinion deal as mentioned above .
Consult one more physician for 2nd opinion.
Good luck.