Yesterday morning I took 2 Fluconazole 200 mg pills around 8 am. I've taken these twice before with no side effect. After eating lunch (avacado, onion, tomato), I became very tired and cold, couldn't get warm. Sat covered in a chair and slept. I felt like I had a reddish rash across my back and I had a stinging/itchy red patch about the size of a quarter on my upper thigh. It was still stinging to touch at bedtime. This morning the deep watermelon colored disc is about the size of a silver dollar and has a yellowish blistery disc about nickle sized on top of the larger one. I don't see any bite marks and I don't know if this leg issue is related to taking the Fluconazole or if it's a separate issue. This spot is very warm to touch. Thoughts? BTW your answer will go to a spamblocker but I will be watching for it. No additional action needed on your part.