Sign-in to Ask A Doctor - 24x7
OR
Sign in with Google
Have Had Irregular Bleeding. Diagnosed With Complex Hyperplasia. Mother Had Ovarian Cancer. Suggest?
Question: I had a uterine biopsy and was dx'd with atypical complex hyperplasia. I have had irregular bleeding for about 1 year, but thought it was related to peri menepause. My mom died at 47 from ovarian cancer, but I had the genetic testing done and I at least don't XXXXXXX one of the markers. How do I know if this condition is 2nd to a progestorone producing tumor.
Brief Answer:
This condition is not caused by progesterone
Detailed Answer:
Hi XXXXXXX XXXXX,
Thanks for consulting us.
The cause of Endometrial hyperplasia is the presence of unopposed Estrogen ( a hormone) for prolonged periods. Progesterone in fact has a protective role & sometimes used in high doses to control the disease.
Irregular bleeding is a sign of anovulation & hence progesterone deficiency ( as is seen in your case).
Conditions that are associated with high Estrogen levels may predispose to Endometrial hyperplasia like obesity, Polycystic ovary syndrome, estrogen producing tumours (e.g. granulosa cell tumour) and any Estrogen replacement therapy.
Endometrial hyperplasia is a significant risk factor for the development or even co-existence of endometrial cancer ( may be in up to 40% of cases), so careful monitoring and treatment is essential.
Hope I have given you the desired response. Please write back if you have any question.
Wish you good health.
Take care.
This condition is not caused by progesterone
Detailed Answer:
Hi XXXXXXX XXXXX,
Thanks for consulting us.
The cause of Endometrial hyperplasia is the presence of unopposed Estrogen ( a hormone) for prolonged periods. Progesterone in fact has a protective role & sometimes used in high doses to control the disease.
Irregular bleeding is a sign of anovulation & hence progesterone deficiency ( as is seen in your case).
Conditions that are associated with high Estrogen levels may predispose to Endometrial hyperplasia like obesity, Polycystic ovary syndrome, estrogen producing tumours (e.g. granulosa cell tumour) and any Estrogen replacement therapy.
Endometrial hyperplasia is a significant risk factor for the development or even co-existence of endometrial cancer ( may be in up to 40% of cases), so careful monitoring and treatment is essential.
Hope I have given you the desired response. Please write back if you have any question.
Wish you good health.
Take care.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
I'm thin, I've never taken oral progesterone or estrogen. I don't think I have had polycyctic disease. Does this automatically increas chances for a co-existing tumour? I have felt sick and tired for about a year... I guess they really wont know until they take out the uterus?
Brief Answer:
Your irregular cycles indicate unopposed estrogens
Detailed Answer:
Hi XXXXXXX
This is good that you are not overweight & have never used any hormones.
I am not aware of your fertility status but as I have mentioned before you have a positive history of irregular cycles. This is a sign of anovulation & may indicate presence of unopposed estrogens, which is a risk factor for this disease.
Yes, you are right only after histopathology & sectioning of the whole uterus they can tell you if there is any co-existing carcinoma or not.
Hope you get well soon.
Best wishes.
Your irregular cycles indicate unopposed estrogens
Detailed Answer:
Hi XXXXXXX
This is good that you are not overweight & have never used any hormones.
I am not aware of your fertility status but as I have mentioned before you have a positive history of irregular cycles. This is a sign of anovulation & may indicate presence of unopposed estrogens, which is a risk factor for this disease.
Yes, you are right only after histopathology & sectioning of the whole uterus they can tell you if there is any co-existing carcinoma or not.
Hope you get well soon.
Best wishes.
Note: Revert back with your gynae reports to get a clear medical analysis by our expert Gynecologic Oncologist. Click here.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Answered by
Get personalised answers from verified doctor in minutes across 80+ specialties
