Question: My wife tested positive for iron poisoning, with an iron reading of 231 and a transferrin saturation of 70%. Mysteriously, her ferritin reads only 27, an impossible combination after scanning almost 100 scolarly documents.
Other than the remote possibility of iron overload related copper and zinc deficiency, what could give this result? Having a liver mri tomorrow.
In 2010 she had a recalled depuy m-o-m hip implant removed, with accompanying massive chromium and cobalt poisoning. YYYY@YYYY
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Dr. Choudhary,
Thank you for your reply.The numbers I gave you WERE a retest of results from last AUG. Iron was 191 in Aug. and 231 in Dec., with ferritin unchanged.All cbc and metabolic panels read normal.
The Aug. test series was done in search of cancer from co-cr metal poisoning, so other out of range factors were ignored until I brought it up. The other flag needing retesting was an epo reading of 45.4, which means the body is scrambling to repair things. Rbc and reticulocytes are low normal. Any comments on why epo is so high and how it ties in to the iron would be appreciated.
Every stage of specialist testing this past year(neurologist, hemo/oncologist, and immunologist) has shown data combinations that doctors say can't be happening. Her gammaglobulins and t-cells are low only for the subtypes that attack chemical toxins(IGg, IGm, cd4 and cd8). Per my own research, everything so far points to xenobiotic antagonists, more than likely co-cr metal oxide nanoparticles, which are powerful oxidizing agents , working catalytically producing ros for over 50 years in the body.
thank you, XXXXXXX

Dr. choudhary,
Thank you again. One more thing I wanted to mention was that for depuy asr hip implants specifically, a frequent occurrence has been false test results indicating presence of a variety of of very rare genetic diseases and other erroneous results.
From my lengthy studies, I attribute this in part to similar physiochemical properties of the period 4 transition elements, where excess of one or more leads to deficiencies of the others, leading to cellular signaling and countless other malfunctions. (atomic # 24-30). Hope this helps.
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Dr. Choudhary,
I really appreciate the effort. If you would include what we are looking for in the abdominal ultrasound that would help.
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Dr. Choudhary,
First, there was no iron in the implant, just co-cr-mo alloy on the bearing surfaces with a titanium femoral shaft.
The ggpt test was normal at 38.
Followup visit revealed no evidence of iron or other abnormalities in the liver mri, other than a single benign cyst. From this the Dr. concluded that the iron overload tests were a false positive due to inflammation, and that no further tests would be authorized, and he quickly left the room. Since iron overload CAUSES inflammation this is a bit of circular logic, plus she is taking effective anti-inflammatories for her osteoarthritis. All 3 of the specialists have abruptly left the room, with fear in their eyes. This implant debris metal oxide nanoparticle toxicity problem is a multidiciplinary situation and it truly takes specialists out of their comfort zone. I would gladly ignore all of the test results if she were not so strongly symptomatic. With the rate of physical deterioration, I believe this is her last year. I guess my only question is suggestions on how to interest new doctors in taking on the case. I'm full of irrefutable research data but short on ideas on how to proceed.
thanks again, XXXXXXX

Dr. Choudhary,
Test results you wanted, bilirubin 0.5, albumin 4.3, and prothrombin never tested.
As to the fear, it is partly because they (understandably) have no answers, and also because I am more informed on the subject, having spent over 2000 hours researching the arthroprosthetic metals phenomenon, so brushoff answers wouldn't work for them.
The most technically revealing document I have read is titled; Use of metal oxide nanoparticle bandgap to develop a predictive paradigm for oxidative stress and acute pulmonary inflammation. This 2012 study by the California nanosystems institute at UCLA is the culmination of 8 years of worldwide research into the toxicity of engineered nanoparticles(in Peggy's case inadvertently engineered), and becomes a testimony to the extreme toxicity of period 4 transition elements in nanoparticle form, including cobalt and chromium.
Also, FDA medwatch last week issued a safety alert for metal on metal implants, stating that afflictions are specific to individual patients, with different patients hving completely different reactions to the debris particles. A good explanation for this would be in the document just mentioned: The bandgap matches the body's redox couple electrical potential, short circuiting cellular signalling, sending erronius instructions systemwide, and in a time and dose dependent manner.
This is why I competely agree with you about the need for medical TEAM efforts to break the code. My attempts to connect her peripheral neuropathy, selective multiple immune deficiencies, debilitating pain and fatigue, high epo, iron overload readings that may or may not be valid, etc., have not been successful, but given that afflictions from hip debris have been declared by the FDA to be randomly individualized I can understand why.
The only valid biomarker would then be a patient presenting with a substantial list of rare and unrelated conditions that would be mathematically impossible to possess save for chronic arthroprosthetic cobalt/chromium exposure. So, the new discipline of attribution science is warranted here.
I would appreciate your input on how I can add to this and any other suggestions.
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Dr. Choudhary,
Thank you so much for informing me about the epo-hepcidin connection. It really put some pieces together. You can help me persuade our hematologist to restart the case if I can pass on sufficient information, as follows:
1. Might epo elevation alone induce enough hepcidin suppression to cause iron overload, and could it signal ferritin to dump it's iron(which was my ORIGINAL question)? Also does there exist a hepcidin test I could request, and are there medications that could raise it?
2. Cobalt chloride ingestion elevates epo by inducing hypoxia like responses thru generation of reactive oxygen species. Autopsies of metal hip patients show substantial storage of co-cr particles in kidney and liver(over 20 milligrams). Could these biopersistent solid cobalt particles induce the same elevated epo response?
3. Her rbc levels since implant have continuously been low or low normal, 3.3-4.0. With her epo exceeding double the upper limit, supposedly raising rbc's, which or all of this list may be or is likely true:
A. Bone marrow not responsive to epo instructions to raise rbc's.
B. Hemolysis is happening too fast for it to keep up. Hemolysis is a known complication of chromium exposure.
C. Oxygen level sensors are sending erroneous signals.
D. An effect of her hormone replacement medications(estradiol and provera).
E. Epo elevation simply a normal response to accelerated tissue repair, possibly due to metal nanoparticle induced redox.
F. Epo resistance developing in the body due to long term elevation.
Hope I haven't asked too much, but getting specialist doctor appointments in the XXXXXXX XXXXXXX area is very difficult unless you're in imminent danger. After the office visit on the 15th he just said come back in 6 months. Being armed with good words is a must. It would also help if you could tell me what you're looking for in the abdominal ultrasound so I could convince him to order the test.
There exist only 3 toxicologists in the state of California and none see patients.
Last week I re-started Peggy on the metal detox regimen that worked so well in eliminating free metallic co-cr from serum after revision surgery. All doctors were tight lipped about detox, so I had to design the mixture myself with a little help from an acupuncturist.
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