What Causes Increased Total Globulin Levels?

Posted on Thu, 16 Feb 2017

Question: Why is total gamma always higher than the m spike number?

And in this case what is the number value of the m spike cause i dont see it.

Thanks

Answered by Dr. Dr. Esmeralda Sera (30 minutes later)

Brief Answer:
Tital gamma

Detailed Answer:
Hello and thank you for asking

Gamma globulin. These proteins are also called antibodies. They help prevent and fight infection. Gamma globulins bind to foreign substances, such as bacteria or viruses, causing them to be destroyed by the immune system

Increased total globulin level:
1-Chronic inflammatory disease - eg, rheumatoid arthritis, systemic lupus 2-erythematosus (SLE).
3-Multiple myeloma.
4-Waldenström's macroglobulinaemia.
5-Hyperimmunisation

Therefore a consultation with your doctor can be useful

Regards

Above answer was peer-reviewed by : Dr. Vaishalee Punj

Follow up: Dr. Dr. Esmeralda Sera (11 minutes later)

Thanks doc. My question is why is total gamma values aleays higher than the actual number value of an m spike?
And based in the study below where can i find the number value in the monoclonal peak?

Answered by Dr. Dr. Esmeralda Sera (18 hours later)

Brief Answer:
About monoclonal gammapathy:

Detailed Answer:
Hello again,
There should be a pathology causing these higher Gamma globulins, but as your lab Doctor suggests further exams are needed.
The IME result does not correspond to the protein electrophoresis, because no peak is seen there. But the lab doctor is responsible to interpret the results in this case and you should follow his suggestions.
Wish you good health.

Best wishes.
Dr.Esmeralda

Above answer was peer-reviewed by : Dr. Remy Koshy

Follow up: Dr. Dr. Esmeralda Sera (14 hours later)

Is there a clinical relation between epstein barren virus and cmv virus with developing mgus and mieloma?

Answered by Dr. Dr. Esmeralda Sera (9 hours later)

Brief Answer:
MONOCLONAL GAMMAPATHY

Detailed Answer:
HI
It's not clear what causes myeloma.Multiple myeloma almost always starts out as a relatively benign condition called monoclonal gammopathy of undetermined significance (MGUS).

MGUS, like multiple myeloma, is marked by the presence of M proteins — produced by abnormal plasma cells — in your blood. However, in MGUS, the levels of M proteins are lower and no damage to the body occurs.

Note: Do you have more questions on diagnosis or treatment of blood disorders? Ask An Expert/ Specialist Now

Above answer was peer-reviewed by : Dr. Kampana