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What Do These Following Colonoscopy And Vaginal Biopsy Reports Indicate?
Question: My name is XXXXXXX and i am a 24 years old Asian girl. In XXXXXXX 2015 I went to the hospital for a check, because my period had been irregular (up to 10 days long instead of the previously 7days) for about 6 month, i was then diagnosed with HPV Positive by an HPV-DNA test (I think was called) there was a number value from the test reported as (3.70 E7). The TCT test came back all negative (stiff cells, Metaplasia cells, Pathogen ..etc) only positive value was Cell Volume >40%. At the bottom of the result paper there was a note like "Diagnosis of a atypical squamous or lesion cells" .
Consequentially the doctors told me that is normal procedure to get a colonoscopy and vaginal biopsy, and so I did.
Results were "low grade cervical lesions" for the colonoscopy (I might report a little bit different terminology but I guess you get the meaning anyway) and found at (6 o'clock) [this is how they describe the location] CIN 1 and at (12 o'clock) CIN 2.
So they suggested me to do the surgery (which consisted in cutting off the part of my cervix with CIN) They kind of give me a choice whether to do the surgery of not but clearly lead me to chose to do it by making some very unpleasant scenario in case i didn't do the surgery, such as could get seriously sick or will have to do the biopsy regularly every 3 months.
The 13th of August 2015 I had the surgery done. The surgery was in their opinion successful. They cut a few pieces some of them as long as 2 cm and as deep as 1 cm. the removed parts were tested and ONLY CIN 1 were found NOW.
After 3 month i was told that I could start having sex again, but every single time I would have a blood loss, in time (like 5 month later) it would become lighter as "pink" but still visible trace of blood on me and on my partner. the doctors keep telling me that this is somehow Normal... up to now july 2016 I have the same problem going on.. again and again.
By the way My period hasn't improve at all, it presents in a dark brownish for the first 2 days or so and becomes then regular color for about 8-9 days. when those 2 days at the beginning with brownish dark blood I don't have the kind of feeling like when my body is really having period.
After 6 month the new TCT test came out with very similar results as the first (all negative (stiff cells, Metaplasia cells, Pathogen ..etc) only positive value was Cell Volume >40%. At the bottom of the result paper there was a note like "Diagnosis of a atypical squamous or lesion cells").
BUT the HPV-DNA test the number value was this time (1.01 E6) instead of the previous (3.70 E7).
What is the difference between E7 and E6? how can it have changed?
I have the feeling that something went wrong
The doctors are now asking me to do another biopsy and NONE of them want to tell me why I have to do that or what are the possible scenario after the test is done! I feel I am losing faith and don't know how to proceed and don't understand why I cannot get a clear answer even if not official answer.. even best against worst scenario answer could be good enough.
I have searched on the net and I saw statistics in which more that 90% of women get healthier again within 2 or 3 years just because their immune system. Is it then worth to wait 2 years or so then check again before do any further surgery or treatment?
Some doctors told me that my boyfriend doesn't need to do any treatment... others told me that yes he should do some treatment as well... where is the truth??
Thanks.
Consequentially the doctors told me that is normal procedure to get a colonoscopy and vaginal biopsy, and so I did.
Results were "low grade cervical lesions" for the colonoscopy (I might report a little bit different terminology but I guess you get the meaning anyway) and found at (6 o'clock) [this is how they describe the location] CIN 1 and at (12 o'clock) CIN 2.
So they suggested me to do the surgery (which consisted in cutting off the part of my cervix with CIN) They kind of give me a choice whether to do the surgery of not but clearly lead me to chose to do it by making some very unpleasant scenario in case i didn't do the surgery, such as could get seriously sick or will have to do the biopsy regularly every 3 months.
The 13th of August 2015 I had the surgery done. The surgery was in their opinion successful. They cut a few pieces some of them as long as 2 cm and as deep as 1 cm. the removed parts were tested and ONLY CIN 1 were found NOW.
After 3 month i was told that I could start having sex again, but every single time I would have a blood loss, in time (like 5 month later) it would become lighter as "pink" but still visible trace of blood on me and on my partner. the doctors keep telling me that this is somehow Normal... up to now july 2016 I have the same problem going on.. again and again.
By the way My period hasn't improve at all, it presents in a dark brownish for the first 2 days or so and becomes then regular color for about 8-9 days. when those 2 days at the beginning with brownish dark blood I don't have the kind of feeling like when my body is really having period.
After 6 month the new TCT test came out with very similar results as the first (all negative (stiff cells, Metaplasia cells, Pathogen ..etc) only positive value was Cell Volume >40%. At the bottom of the result paper there was a note like "Diagnosis of a atypical squamous or lesion cells").
BUT the HPV-DNA test the number value was this time (1.01 E6) instead of the previous (3.70 E7).
What is the difference between E7 and E6? how can it have changed?
I have the feeling that something went wrong
The doctors are now asking me to do another biopsy and NONE of them want to tell me why I have to do that or what are the possible scenario after the test is done! I feel I am losing faith and don't know how to proceed and don't understand why I cannot get a clear answer even if not official answer.. even best against worst scenario answer could be good enough.
I have searched on the net and I saw statistics in which more that 90% of women get healthier again within 2 or 3 years just because their immune system. Is it then worth to wait 2 years or so then check again before do any further surgery or treatment?
Some doctors told me that my boyfriend doesn't need to do any treatment... others told me that yes he should do some treatment as well... where is the truth??
Thanks.
Brief Answer:
do not worry
Detailed Answer:
Hi there,
Welcome to HCM,
HPV (human papilloma virus ) has more than 100 types and are classified by the type of protein they carry so thats why the E7 and E6 difference that you are getting on your repeat result.
Another thing is that HPV virus in most young women get cured themselves in a couple of years, but if they cause changes in cervical cells like in your case showing CIN 2 then it is unlikely that the virus will go away on its own.
HPV is the cause of cervical cancer in 99% of the cases, so if the infection is causing CIN 1/2 changes then it's necessary that treatment is taken and long term follow up to identify cervical cancer if at all it happens becomes necessary.
Your partner does not need treatment, as though its sexually transmitted once exposed to the virus there is no as such medical treatment in men for the same.
In women who have CIN changes the treatment is surgical procedures like the one you have had.
Your treatment uptill now has been correct.
The repast procedure as the cells are still atypical is justified. The cells should have shown normalcy at repeat smear of 6 months after procedure.
Do not be confused.
CIN 2 has a less than 30% chance of turning into cervical cancer after 10 years, but if you follow up with your doctor and get treated it will not be a concern.
Hope I have solved some of your queries.
Regards.
do not worry
Detailed Answer:
Hi there,
Welcome to HCM,
HPV (human papilloma virus ) has more than 100 types and are classified by the type of protein they carry so thats why the E7 and E6 difference that you are getting on your repeat result.
Another thing is that HPV virus in most young women get cured themselves in a couple of years, but if they cause changes in cervical cells like in your case showing CIN 2 then it is unlikely that the virus will go away on its own.
HPV is the cause of cervical cancer in 99% of the cases, so if the infection is causing CIN 1/2 changes then it's necessary that treatment is taken and long term follow up to identify cervical cancer if at all it happens becomes necessary.
Your partner does not need treatment, as though its sexually transmitted once exposed to the virus there is no as such medical treatment in men for the same.
In women who have CIN changes the treatment is surgical procedures like the one you have had.
Your treatment uptill now has been correct.
The repast procedure as the cells are still atypical is justified. The cells should have shown normalcy at repeat smear of 6 months after procedure.
Do not be confused.
CIN 2 has a less than 30% chance of turning into cervical cancer after 10 years, but if you follow up with your doctor and get treated it will not be a concern.
Hope I have solved some of your queries.
Regards.
Above answer was peer-reviewed by :
Dr. Veerisetty Shyamkumar
There are a couple of things that you didn't answer:
By the way My period hasn't improve at all, it presents in a dark brownish for the first 2 days or so and becomes then regular color for about 8-9 days. when those 2 days at the beginning with brownish dark blood I don't have the kind of feeling like when my body is really having period. (why is that?)
up to now July 2016 every single time I have sex I would have a blood loss (lighter as "pink" but still visible trace of blood on me and on my partner) I have the same problem going on.. again and again.
How long typically takes to completely recover after such surgery
If my boyfriend got in contact with HPV as well but there is no treatment for him, does it mean that he will "re-infect" me with HPV again and again even after I will have eliminate the virus surgically or in other ways?
By the way My period hasn't improve at all, it presents in a dark brownish for the first 2 days or so and becomes then regular color for about 8-9 days. when those 2 days at the beginning with brownish dark blood I don't have the kind of feeling like when my body is really having period. (why is that?)
up to now July 2016 every single time I have sex I would have a blood loss (lighter as "pink" but still visible trace of blood on me and on my partner) I have the same problem going on.. again and again.
How long typically takes to completely recover after such surgery
If my boyfriend got in contact with HPV as well but there is no treatment for him, does it mean that he will "re-infect" me with HPV again and again even after I will have eliminate the virus surgically or in other ways?
Brief Answer:
no worries
Detailed Answer:
Hi there,
The period is due to shedding of lining of the womb, and I do not think it is related to the CIN in any way. But having a period for 10 days (2 days mild and 8 days the regular flow) is not normal, and you should get an pelvic ultrasound and hormonal levels checked for that.
It usually takes around 6 months after the procedure for no intermittent spotting to occurs, but if you have spotting and atypical cells on the smear it could be due to the CIN itself, so best to do a biopsy and then take treatment according to the result.
Once the CIN is clear it should take months or so for the spotting to stop.
HPV of your partner can reinfect you but only if its a different strain. every time a Different type only can cause infection , once you are infected with one type (say E6) then your body recognizes it and next time even if you are exposed to it you will not get reinfected.
Use condoms till all this is sorted out, that would be the best way to prevent any added exposure to HPV.
Do get the biopsy done soon, as that will answer if you still have CIN and which grade it is, depending on that further treatment can be advised.
Hope this helps.
Regards.
no worries
Detailed Answer:
Hi there,
The period is due to shedding of lining of the womb, and I do not think it is related to the CIN in any way. But having a period for 10 days (2 days mild and 8 days the regular flow) is not normal, and you should get an pelvic ultrasound and hormonal levels checked for that.
It usually takes around 6 months after the procedure for no intermittent spotting to occurs, but if you have spotting and atypical cells on the smear it could be due to the CIN itself, so best to do a biopsy and then take treatment according to the result.
Once the CIN is clear it should take months or so for the spotting to stop.
HPV of your partner can reinfect you but only if its a different strain. every time a Different type only can cause infection , once you are infected with one type (say E6) then your body recognizes it and next time even if you are exposed to it you will not get reinfected.
Use condoms till all this is sorted out, that would be the best way to prevent any added exposure to HPV.
Do get the biopsy done soon, as that will answer if you still have CIN and which grade it is, depending on that further treatment can be advised.
Hope this helps.
Regards.
Note: Revert back with your gynae reports to get a clear medical analysis by our expert Gynecologic Oncologist. Click here.
Above answer was peer-reviewed by :
Dr. Prasad
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