Brief Answer: Kindly provide important details Detailed Answer: Hello, Welcome and thanks for posting your query to the forum. I can understand your concern for tremors and red rash bilateral hands, flushed warm skin, difficulty swallowing like lump in back of throat along with increased irritability in yourself after taking Accutane. The query provided is brief to guide you best for the concern. It would be best if you can provide additional information so that I can guide you best regarding your condition. I request you to please elaborate the condition in terms od : - For what exact condition you started Accutane. -What is the dose of accutane that you are taking per day. - Since exactly how long you started with all the symptoms you have mentioned. - Can you elaborate precisely the time sequence and appearance of one symptom after the other (like does the rash was first and then tremors and irritability) - Any other systemic illness or medicines you are taking. Hope to hear soon from you. With regards, Dr Sanjay Kumar Kanodia MD -Dermatology

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Brief Answer: Isotretinoin should be stopped for a while Detailed Answer: Hello XXXXXXX Thanks for sending all the important details for the interpretation of your condition. After analyzing the situation with diligence I can make out a possible side effect of Accutane (Isotretinoin). To tell you medically - In general the recommended dose of Isotretinoin is in between 0.5 to 2mg but in clinical practice we generally start with a dose of close to 0.5 mg per day. In this scenario the dose comes close to less than 30 mg per day in your case. I generally start even lower dose of 20 mg per day in my patients. Isotretinoin is one of the gold standard therapy for cystic acne but the only disadvantage is the side effects. All the symptoms mentioned by you can be part of adverse events of Isotretinoin. It can cause rash, redness on skin and flushed appearance of skin. There can be dryness in throat which can cause difficulty in swallowing. Additionally there can be rise in intracranial tension leading to basically headache and central nervous system symptoms. I suggest you to stop the drug immediately and talk to your treating dermatologist to check for the side effects as well your blood profile. If I were your treating dermatologist then I would have preferred to stop the drug for 1-2 weeks and then simultaneously have gone for blood profile including liver profile and fat profile. If the symptoms are alright in 2 weeks and blood profile is fine then i would have restarted the drug in low dose of 20 mg per day. There is no interaction of the low dose estrogen pill for birth control as well adderal with Isotretinoin, so you can take all these drugs. You do not worry about the side effects as are temporary in nature and can be very easily controlled but under dermatological supervision only. So talk to your treating doctor and tell him/her regarding your present side effects which can be controlled either by temporary cessation of drug or reducing the dug to minimal optimal dose. You will be alright soon and do not worry about these temporary side effects. I hope these information will help you. If you have any further queries then I will be glad to help. With regards, Dr Sanjay

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