Hello, Since those drugs were prescribed by her doctor, you don t have to worry. Because no doctor wants to do harm to their patients. Duphaston contains dydrogesterone that has been used worldwide. Dydrogesterone is safe to use during pregnancy only when prescribed and indicated by her treating doctor. So does Gestofit. Gestofit is progesterone. Progesterone is essential for pregnancy and where there is lack of it often leads to miscarriages. So this drug is preventing miscarriages that tend to occur in your wife s condition. Make sure your wife take those drugs as prescribed. Routinely take your wife to her obstetrician. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Nurul Falah