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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can IV Globulin Treatment Reduce WBC?

I ve had CLL for the past 12 yrs. My WBC have been between 18,000 & 22,000. On June 2012, it was 21,000. I had a bad upper respiratory infection in Oct 2012. My PCP put me on antibiotics. He also recommended that I have a full blood test. My results showed that my WBC spiked from 21,000 to 30,000. He ordered another test and was tested 6 days later and my WBC went to 35,0000. He recommended that I see a Hematologist and referred me to the Norris Cotton Cancer Center in Manchester, NH. This hematologist is one of the best in NH and he has also done a lot of research on his own. The hematologist ordered a complete blood test of my blood. My WBC spiked to 51,000 from Dec. 18 to Jan 2nd. . The hematologist concluded that my globulin level was low and that was why my WBC spiked and are keeping rising. I m starting treatment next Thursday with IV globulin treatment. He s recommending that I have 6 treatments. I m relieved that s it s not chemotherapy. I would like to know if I have to change my lifestyle during the treatment, is it going to affect my work, and or sports? I don t have any ailments from CLL, like lymph swelling, fever or anything like that. The only thing I know is that my counts are high and are increasing. Otherwise, I don t have any symptoms. I would also like to know if this treatment will reduce the WBC. I m under the impression that because my globulin levels are low, it s causing my WBC to rise. Also, once I conclude this treatment, are my WBC go back to normal? Please advise. Thanks.
Wed, 5 Feb 2014
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Oncologist 's  Response
Dear ,
Thank you for genuine query. Normally CLL does not require any treatment until it is symptomatic. Blood counts do go up when there is reduction in the body immunity which is a common problem in CLL. In the infective stage it is not the lymphocytes but granulocytes which increase in number to be verified by DLC. Immunoglobulins will definitely increase your immunity to infections and WBC count may fall if it is infective nature but if your counts still go up you need to undergo proper management.
Dr. J. Ticku
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Can IV Globulin Treatment Reduce WBC?

Dear , Thank you for genuine query. Normally CLL does not require any treatment until it is symptomatic. Blood counts do go up when there is reduction in the body immunity which is a common problem in CLL. In the infective stage it is not the lymphocytes but granulocytes which increase in number to be verified by DLC. Immunoglobulins will definitely increase your immunity to infections and WBC count may fall if it is infective nature but if your counts still go up you need to undergo proper management. Dr. J. Ticku