I know I am supposed to take my cholesterol med at bedtime. If true, it would make sense to avoid fatty foods especially in the evening, and having some fruit and tea before bedtime, high in anti-oxidants, would be a good idea. On the opposite end, I used to have a peanut butter sandwich, and maybe ice cream, and a piece of cheese in the evening. Also a pice of fruit sometimes, or orange juice. My coronary arteries were heavily blocked, and I needed an emergency triple bypass. I had no typical risk factors for coronary artery disease. Let s play a game. Some of you do what I did, and some eat a piece fruit in the evening. Let s see who gets heart disease or heart attacks in the next five years. Oxidized LDL cholesterol, small and dense, is sucked up by monocytes in the damaged arterial lining, bulging the arterial wall. Anti-oxidants keep the LDL big and fluffy , and away from the monocytes, where the LDL is mainly harmless in the blood stream. The medications reduce the amount of LDL in the blood stream.