Hi, I had gone through your query and understand your concerns.I will do my best to help you. Minivelle -Transdermal Estradiol -smallest estrogen patch therapy used -may have side effects like Headache,breast tenderness, stomach Stomach upset cramps nausea,sometimes vaginal spotting or irregular bleeding. Prometrium -Progesterone -may have side effects like sudden headache,chest pain ,chills,cold or flu like symptoms,cough ,hoarseness or sometime fever,urination problems. - Antacids can provide relief which are to taken with Physician consultation. Minivelle may be the cause for persisting stomach cramps but there also various other etiology for cramps which need to ruled out .Hence I suggest to consult the treating Doctor or Physician at the earliest for detailed evaluation I hope that I have answered your questions fully and been of some help. If you have anymore questions please contact me again anytime Regards, Dr.Sushma