I need to know if a combination of medications can cause severe migraines. Most of the medications have been taken for years, a couple have been a little over a year. Seroquel 300 mg twice a day, gabapentin 1200 mg nightly, mirtazipine 45 mg nightly, trazadone 300 mg nightly, methenamine hippurate 1 gm 6 pm, hydroxyzine hcl 50 mg nightly. Seroquel, gabapentin, mirtazapine and trazadone have been taken for over 6 years, the methenamine and hydroxyzine have been about 1 1/2 years. Just started getting massive migraines for the past month. Could the mixture cause the migraines?