Can smoking 1ppd for 23 yrs cause swollen painful feet and ankles? Am 50 y/o female current smoker. Neuropathy from past etoh abuse, copd, some varicose veins, worked on my feet 45+ hrs a wk last 25 yrs. Best in midday, worse in eve and much worse first thing in morning. Also severe OA. On gabopentin but no OA meds. Sciatica and herniated discs L2-S1. 5 4 , 175 lbs