Dear madam i can understand your concern There is nothing to get alarmed because this is a natural happening in the course of diabetes progression. the medication novonorm might not be of much use since due to long course of diabetes there might be reduced pancreatic output of insulin. then taking human mix three times along with novorapid is not advisable instead i would like to suggest you a new and easily manageable regimen called basal bolus regimen. this regimen consist of usage of lantus once during bed time and novorapid before meal i would like to know what problem you are facing with glucophage? i also suggest you to consider using medications like januvia and galvus with will protect your pancreas and reduce hunger. i will be waiting for your reply Hope I was able to help you. If you have any further question feel free to write me back. I will be happy to help. Take care. Best Regards. Dr Vamsi Krishna Consultant Diabetologist Apollo Hospitals MUSCAT