Thanks. I have Clinical Depression, which is now under control, however recently I had an upset. Consequently, my GP (currently overseas) has given me a script for Avanza to try. I am on 100mg Zoloft in the mornings, and 10 mg Endep at night. My query is, after 17 years of being on Endep, should I come down off it gradually, and gradually replace it with the Avanza? Or should I be taking both still? Thanks.