Hi there, Thanks for your query. Firstly, none of the prescribed drugs are sulpha drugs. You may switch over from Losartan to Amlodipine in titrating doses to control your blood pressure, which would relieve you of your problems. Continue Toprol. Further, GERD is most commonly due to infection of the stomach by a bacteria (called H.pylori). A 2-weeks course of anti-H.pylori therapy (available in the form of kits); followed by 3-4 months of Nexium- will cure your GERD permanently. Loss of voice is probably due to recurrent reflux of stomach acid. Saline gargles (with 4 spoons of salt in a glass of hot water) 3-4 times a day should help bringing back your voice. Consult an ENT doctor, if the problems persist. Consult your doctor and apprise him of my opinion. I am certain that he agree with me, order required tests, and- based on the reports- will prescribe suitable treatment as advised. If you find my response helpful and informative, do not forget an “excellent” (5-star rating) to my answer, to ENCOURAGE all doctors- engaged in social service- to render sound advice to the FREE queries. Fond regards and have a nice day Dr. Rakesh Karanwal