I had been taking minivelle 0.1 mg twice a week. I decided to go off of them for a while. After about 3 months of not using them, I couldn t take the hot flashes, sweats, and had anxiety. I have been using them again for 3 days and none of my menopausal symptoms have eased up. Why are they not working now? When I first started taking them, the relief was almost instant.