Hi Dear, Welcome to HCM. Understanding your concern. As per your query acne problem since years which occur when there is hormonal changes, stress and clogged pores of sebaceous gland filled with sebum ,dead skin and bacteria get infected. You are already taking so much medicine but not get benefited. I would suggest you to drink plenty of water daily and add fresh fruits and vegetables to your diet. Take Multivitamin supplements. Apply Adapelene gel once at night. If condition doesn t start getting better in a month then consult dermatologist. Doctor may prescribe antibiotics course and can also go for chemical peel containing Glycolic acid. Apply Meladerm cream and it is purely safe to use as this is combination of hydroquinone, Tretinoin and steroid and apply it at night time. Hope your concern has been resolved. Get Well Soon. Best Wishes, Dr. Harry Maheshwari