My daughter broke out in hives less then 24 hours after receiving the flu shot. She also had pain in her leg so bad she wouldn t walk. That was in October. She has a slight cold now and hives came back along with pain in her leg. It is ok during the day but at night it keeps her from getting a good sleep. It has affected both legs at different times. We have an appointment with a rhuematologist Wednesday. I just don t know how to keep her comfortable at night. I have her on ibuprofen every 6 hours and zyrtec liquid at night because of the hives. The hives are gone. Her skin is really sensitive and the doctor wants her on zyrtec for 3 weeks. I am so upset by all of this I can t sleep. Any suggestions?