Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. Clostridium difficle infection occurs when the normal good bacteria in our gut is killed by too many antibiotics and bad bacteria grow too much. To replace the normal gut bacteria she must eat lots of CURD and yogurt. Daily stop all antibiotics and use probiotics like sporolac etc. Only overuse of antibiotics will lead to this condition. For sinus infections do use steam inhalation, nasal decongestents and for urine infections ask her to take plenty of water, avoid postponing urination and personal hygiene. She can be given antibiotics like tab nitrofurantoin for urinary infections which usually doesn t cause c difficle diarrhea. That too take upon doctors prescription and after urine culture test. Hope I have answered your query. Let me know if I can assist you further.