Hi. Thanks for your query. Noted the history and understood the concerns. Symptom-complex of fatigue, lack of appetite, constipation, palpitations, light headedness, especially in the morning can be due to many a causes but addition of crevices at the edge that is most probably angle of mouth also called Cheliosis indicate that you have multivitamins deficiency, particularly folic acid and others. There may be colitis or any other medical disorder as the original cause that increase your symptoms and signs one by one. I would advise you the following in such situation: Get the stool, blood and urine tests as per the clinical evaluation by your Doctor to get a proper diagnosis and also to go for further investigations like colonoscopy, CT scan of abdomen if needed to get the proper diagnosis so that a proper treatment can be done. Take multivitamins, Folvite that is Folic acid, Lycopene, trace elements and mineral. Once the diagnosis is made, go for specific treatment. Continue the management with multivitamins as it takes time to cover dully. Also go for healthy diet and take supplements as needed.