Hello, Canker sores and viral conditions can cause discomfort. More time may be needed to allow your body to heal. Try to take some anti-inflammatory medication such as Advil and Tylenol. If you are experiencing a great deal of discomfort take a combination of two Advil and two Tylenol at regular intervals. Rinse your mouth often with an antiseptic or warm salt water. Keep well hydrated and make sure you do not have any deficiencies in your diet or vitamins. Take some vitamin B12. Change your toothbrush and make sure you are properly cleaning your TMJ splint. Inspect your appliance for any damage or buildup such as plaque and tartar. Have your dentist inspect the appliance and assist you in cleaning it if needed. There is a possibility that you now have an oral yeast infection. Acidophilus may help prevent this. You may require a prescription for Nystatin, an anti-fungal medication. See your physician if your systemic symptoms persist or worsen for a diagnosis and possible medications. Thank you for your inquiry. I hope my suggestions are helpful to give you some relief and that you feel better soon.