Hello, The most common side-effects of sulfasalazine are nausea (feeling sick), diarrhea, stomach pain, dizziness, headache and skin rashes. These side-effects usually occur during the first three months of treatment and often clear up if the dose is reduced. You may be able to increase the dose again after a time if your tolerance improves and if the sulfasalazine is helping your symptoms. Taking sulfasalazine can affect your blood count or your liver, but these effects can be picked up at an early stage by regular blood tests. You may be asked to keep a record of your blood test results in a booklet and to take this with you when you visit your GP or the hospital. You should tell your doctor of rheumatology straight away if you develop any of the following after starting sulfasalazine: A sore throat, fever or any other symptom of infection, unexplained bruising; any other new symptoms or anything else that concerns you. Your urine may change color (to orange) with sulfasalazine but this is nothing to worry about. Sulfasalazine may also stain your tears and soft contact lenses yellow. You should see your doctor immediately Hope I have answered your query. Let me know if I can assist you further. Take care Regards, Dr AJEET SINGH, General & Family Physician