Hello, Thanks for posting on HCM, You are experiencing some side effects of gupisone (generic name: prednisolone) and this means you should contact your doctor as soon as possible. These are some of the side effects that you may experience while taking this drug: - Bone pain - Dizziness - Fast, slow, or uneven heartbeat - Fever, chills, cough, sore throat, and body aches - Headache, trouble seeing, or eye pain or swelling - Muscle weakness, cramps, pain, or aches - Numbness, tingling, or burning pain in your hands, arms, legs, or feet - Pain in your lower leg (calf) - Swelling in your hands, ankles, or feet. - Rapid weight gain In other words you may even develop cushing s syndrome while taking this medication. I will suggest you talk to your doctor as soon as possible to discuss possibilities of discontinuing the drug or changing. Hope this helps