Hi, welcome to our site. I am Dr Saumya Mittal- Physician and Diabetician Read your query. That is a very significant question and i appreciate your problem. I will try my best to answer your query One needs to understand what exactly is insulin resistance. It means that the insulin being produced may not be of the right type for the cells in the body. There is no question of DNA change. So the DNA remains the same as the DNA you started out with. What happens is that the insulin you produce is not enough. One of the most resistant tissue is the adipose tissue- simply put, the fat. When you exercise and eat right, the fat reduces. So the insulin wasted on the excess fat is spared for use elsewhere. So when you exercise and diet and manage to reduce weight, the fat reduces. And the insulin can be spared. On the other hand, cells that naturally use the glucose like the muscle cells pick up more glucose from the blood. therefore again insulin is spared. So again the resistance comes down (Please note- this is just a brief way to explain to you what happens, the actual science could take volumes) I hope this helps you. Inform the reports mentioned above so i can be of help further. Best of luck. I have given you the answer to the maximum considering the information provided. The results of the tests could further enhance my answer to you. Please do understand that some details could be extracted from a detailed history and examination. Looking forward to your return query with the details asked so that I can help you further. (If the answer has helped you, please indicate this)