The other names for the same syndrome are these below:
1) Vasoactive intestinal peptide-producing tumor
2) Pancreatic endocrine tumor
3) Verner-Morrison syndrme
4) Pancreatic cholera
5) WDHA syndrome Watery diarrhea , hypokalemia and achlorhydria.
VIPoma causes cells in the pancreas to produce high levels of a hormone called vasoactive intestinal peptide (VIP).
This hormone increases secretions from the intestines and relaxes some of the smooth muscles in the GI system.
The cause is not known.
VIPomas are usually diagnosed in adults, most commonly at age 50.
Women are more likely to be affected than men.
This cancer is rare, affecting an estimated 1 in 10 million people per year.
Watey diarrohea(100 %), hypokalemia (80-100%),dehydration(83%),hypochlorhydria(54-76%) and flushing (20%).
The first goal of treatment is to correct dehydration.
Fluids are often given through a vein (intravenous fluids) to replace fluids lost in diarrhea.
The next goal is to slow the diarrhea. Some medications can help control diarrhea.
Ocreotide, which is a man-made form of a natural hormone(Somatostatin analouge), blocks the action of VIP.
The best chance for a cure is surgery to remove the tumor.
If the tumor has not spread to other organs, surgery can often cure it.
Cancer spread (metastasis)
Cardiac arrest from electrolyte imbalances
Dehydration
Surgery can usually cure VIPomas.
However, in one-third to one-half of patients, the tumors have spread by the time of diagnosis and are not curable.