Hi Chobbs, Thanks for writing in. I am a medical specialist with a degree in subspecialty of cardiology. I saw your screening and siund low seum B12, low Iron, Srum positive for antinuclear antibody. Additionally, you have borderline elevation of total cholesterol and LDL. ANA shows up on indirect immunofluorescence as fluorescent patterns in cells that are fixed to a slide that is evaluated under a microscope. Different patterns have been associated with a variety of autoimmune disorders, some of the more common patterns include: Homogenous (diffuse) - associated with SLE and mixed connective tissue disease Speckled - associated with SLE, Sjogren syndrome, scleroderma, polymyositis, rheumatoid arthritis, and mixed connective tissue disease Nucleolar - associated with scleroderma and polymyositis Centromere pattern (peripheral) - associated with scleroderma and CREST (Calcinosis, Raynaud s syndrome, Esophogeal dysmotility, Sclerodactyly, Telangiectasia) It is not possible to diagnose the exact cause for this without examining you and perhaps doing some more tests. Your doctor has done the right thing in referring you to rheumatologist. Best Wishes Dr Anil Grover