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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Does The Development Of Rhogam Mean Erythroblastosis Fetalis Is No Longer Seen?

Prior to the development of Rhogam , a woman with blood type O- giving birth to a baby with blood type A+ had a 2% chance of developing an immune response and producing anti-Rh antibodies . A woman with blood type A- giving birth to a baby with blood type O+ had a 16% chance of immune response. Why do you think there such a large difference in risk? Why was the risk not higher in either case? How does Rhogam decrease this risk? Does the development of Rhogam mean erythroblastosis fetalis is no longer seen?
Tue, 9 Oct 2012
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Pediatrician, Neonatology,  's  Response
Hi,
Previously it was seen and thought that ABO incompatibility protects against pregnancy induced Rh hincompatibility.But there were some reports that it is always not so.
There is a remarkable improvement in management of RH incompatibility after routine introduction of Rhogam! We,the Neonatologists do not see the bad neonatal naundice cases,hydrops from RH incompatibility.In fact exchange transfusion of blood in newborns has dramatically reduced now!thanks to innovations.
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Does The Development Of Rhogam Mean Erythroblastosis Fetalis Is No Longer Seen?

Hi, Previously it was seen and thought that ABO incompatibility protects against pregnancy induced Rh hincompatibility.But there were some reports that it is always not so. There is a remarkable improvement in management of RH incompatibility after routine introduction of Rhogam! We,the Neonatologists do not see the bad neonatal naundice cases,hydrops from RH incompatibility.In fact exchange transfusion of blood in newborns has dramatically reduced now!thanks to innovations.