hi, Hemochromotosis is a disease mostly defined as iron overload with a hereditary/primary cause or originating from a metabolic disorder or multiple blood transfusion. 1) For the first question about cirrhosis - Answer is yes she will have high chances for cirrhosis of liver 2) For the second question about what could be done - answer is reduce the amount of iron in blood- by blood donation/ by using chelating agents which help to change the iron in different compound. Now let me evaluate the condition of your mother. a)her age is 80 yrs b)She already has low platelets and enlarged spleen. c) chronic arthritis (probably due to excess of iron deposition). d) issues with bruising and slow healing. Now about the therapy option 1) blood donating - chances of prolonged bleeding, infection at sight of donation, already low platelets 2) chelating therapy - (Serious and potentially fatal side effects, which are very rare, include heart failure; a sudden drop in blood pressure; abnormally low blood levels of calcium; permanent kidney damage; and bone marrow depression ) advice: looking at her age and benefit to risk ratio for medication seem reasonably tending more toward risk side, my opinion is to let nature take its course as our intervention will probably cause more harm the benefit as well as even we will try to increase her life span , the quality of remaining life will not be as good as if nature will take course and had little bit short life span, may be by 6months or so!!