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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Never Smoked. Heart Caths Have Long Showed No Blockage. Developed Peripherial Neuropathy. Now Feel Fatigue. Connected?

I'm male, 76, never smoked. Heart caths have long showed no blockage. I had several URI's [onset five yearsa go] which were treated with quinolones. At the midpoint of the floxin "deluge" I developed a severe peripherial neuropathy [the legs are now Jello]...and [shortly thereafter] a disabling [fatiguing] CHF as well. Any connection between the two maladies? Can you furnish "links" to allow me to study this inmore detail?
Thu, 22 Aug 2013
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Cardiologist,  's  Response
Dear patient,

Thanks for your health concerns. Indeed, some of the quinolones, particularly gatifloxacin, have been associated with peripheral neuropathy, although usually transient. It is in the differential diagnosis but also other metabolic/ systemic causes are possible for a peripheral neuropathy, including diabetes and B12 deficiency, both which can have fatigue as part of the presentation. Very very rare, but thiamine deficiency, also known as beri-beri, can give both CHF and neuropathy. Amyloidosis is another cause of CHF and neuropathy. I would encourage you to consult a provider, specifically a neurologist, who would be able to conduct an initial basic workup for neuropathy

Yours truly,

Dr Brenes-Salazar MD
Cardiology
Mayo Clinic MN
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Never Smoked. Heart Caths Have Long Showed No Blockage. Developed Peripherial Neuropathy. Now Feel Fatigue. Connected?

Dear patient, Thanks for your health concerns. Indeed, some of the quinolones, particularly gatifloxacin, have been associated with peripheral neuropathy, although usually transient. It is in the differential diagnosis but also other metabolic/ systemic causes are possible for a peripheral neuropathy, including diabetes and B12 deficiency, both which can have fatigue as part of the presentation. Very very rare, but thiamine deficiency, also known as beri-beri, can give both CHF and neuropathy. Amyloidosis is another cause of CHF and neuropathy. I would encourage you to consult a provider, specifically a neurologist, who would be able to conduct an initial basic workup for neuropathy Yours truly, Dr Brenes-Salazar MD Cardiology Mayo Clinic MN