Hello Daomingsi, Hope my answer will be of help here. Pulmonary TB when diagnosed usually have a 1st line treatment of Rifampicin + Isoniazid + Pyrazinamide + Ethambutol which are taken for the first two months, then switched to 2 medications Rifampicin + Isoniazid given 3 times a week for next 4 months (2RHEZ/4RH). This regime is recommended by WHO, CDC and other well known international organizations. They insist on patients following the treatment through and rigorously. When situations like resistance to first line therapy, extensively drug-resistant tuberculosis (XDR-TB) or multidrug-resistant tuberculosis (MDR-TB) arise, a second line treatment is recommended. Only your doctor has the right to place on 2nd line or 3rd line as they are some specific guidelines to follow as recommended by WHO. It is possible that your brother might be having an associated illness that came later on in the course of his treatment. If your brother was diagnosed in 3rd May 2012, and his treatment started right away, it means he must have been taking his treatment already for over 7 months already. Is there a particular reason why he is still on quadtab up till now? She should have been switched to isoniazid and rifampicin only regimens months ago and by now he must have completed his treatment already. If his doctor decided to place him on a 9 months regimen ( for reasons that are not really clear with respect to your own brother s presentation), he still had to be on only two drug regimens by now. My suggestion is for you to meet his doctor and discuss his regimen with him. As for the side effects, they could be managed symptomatically. Normally treatment of pulmonary TB requires a series of checks up like chest x-ray and blood tests/sputum test and also clinical evaluations which would tell the doctor if his treatment is working or not. Because for treatment failure or drug resistance. They are specific regimens that need to be followed. Hopefully this helps with your brother s condition