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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Elevated Tegretol Level?

If a person has a normal tegretol level 7.7, (earlier that week)then has a UTI, prescribed antibiotics, becomes dehydrated goes to ER, but takes his prescribed Tegretol before going to ER, Has level of 18.3 on admit and later same day has level of 21.2. Would this rise be from the dehydration and or the antibiotic or both? If he gets sick again, should we expect this?
posted on Fri, 14 Mar 2014
Twitter Thu, 4 Sep 2014 Answered on
Twitter Thu, 4 Sep 2014 Last reviewed on
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Internal Medicine Specialist,  's  Response
Hello,
although the information you provided is not sufficient for a complete answer, I'll give you two possible explanations of carbamazepine levels elevation on this particular situation. Kidney functionality should be stable for the levels to be stable as well. A dehydrated person is likely to have impaired kidney function which means that less carbamazepine (the active ingredient of tegretol) is excreted to the urine. Keep in mind though that only a small amount of carbamazepine is directly excreted through the kidneys.
Another possible explanation is the administration of other drugs (the antibiotics you mentioned). Certain drugs may cause slower clearance of other drugs (or the opposite). This may eventually lead to elevated (or decreased) plasma levels of the drug.
Nobody can say for sure if levels will rise in case he gets sick again. It depends. Under the same circumstances though, expect similar results.
I hope I've answered your query. Don't hesitate to ask again, if you need more information.
Kind Regards!
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What Causes Elevated Tegretol Level?

Hello, although the information you provided is not sufficient for a complete answer, I ll give you two possible explanations of carbamazepine levels elevation on this particular situation. Kidney functionality should be stable for the levels to be stable as well. A dehydrated person is likely to have impaired kidney function which means that less carbamazepine (the active ingredient of tegretol) is excreted to the urine. Keep in mind though that only a small amount of carbamazepine is directly excreted through the kidneys. Another possible explanation is the administration of other drugs (the antibiotics you mentioned). Certain drugs may cause slower clearance of other drugs (or the opposite). This may eventually lead to elevated (or decreased) plasma levels of the drug. Nobody can say for sure if levels will rise in case he gets sick again. It depends. Under the same circumstances though, expect similar results. I hope I ve answered your query. Don t hesitate to ask again, if you need more information. Kind Regards!