Dear Sir, I am 68yrs Type IIDM,I had no previous history of HTN before july 2010.I lost my left eye due to thrombosis in left eye.Intra-occular presssure in july was 60 in left eye. I take Thyronorm,Zomelis(Vidagliptin),Xirtam-40,(Olmesteran-Medoximil),Urimax-D,Modlib-10(Astrovastatine),Clavix-75(Clopidogrel) and take Humalog Mix-Insullin (Protamine suspension) and Nebicard-5(Novivolol),My Lipid Profile is within normal range,Creatinine is within 1.3 to 1.6 range for last one year.TSH is on the border line. PSA is normal,Prostate is slightly englarged f38gms. My problem is my sytolic pressure remain high spcially 6pm onwards but diastolic pressure remain low(170/65) and after taking Nebicard-5(Beta blocker) pulse reduce to 58. .Some times pain on the top of the head. To doctor said it is Isolated systolic HTN. and prescribed celcar5 along with nebicard 2.5. How I can comeout from this problem and if systolic pressure continues higher for a long period of time what would be the adverse effect in the long run?.