Hello, I just turned 50, about 6 months ago my new doctor put me on premarin .625 to help with hot flashes. I had my uterus removed when I was 25 after having two babies, I still have my ovaries. I started having night sweats about a year ago. My previous doctor retired and this new one thought I needed meds. I recently noticed having swelling in my ankles, my breast hurt very badly and swollen, nipples stick out like I am cold all the time and the mental issues, anxiety, depression, anger. I read online where these could be caused by the premarin. I stopped taking the premarin 3 days ago. I felt better yesterday but this afternoon started feeling hot and not well. What do I need to do to have normal feelings in my breast and mental health again.