I have raised cholesterol levels, hypothyroid, pernicious anemia and chronic kidney disease . i have had a sore mouth, throat and neck for a year. My tongue is permanently sore. is it connected to one of my conditions? I am permanently tired and out of breath with the slightest exertion ie walking up stairs i have to rest half way up. I take 50 mg levothyroxine per day and have B12 injectons every 3 months but I am swollen in my face, hands, legs and stomach and have put on a stone in weight. My urine output has fallen drastically.