Hello, I had a biopsy 9 months ago and it was positive for subacute cutaneous lupus. But my blood work is normal. I have a rash on my face, chest arms , inner thighs and calves . The rash does not go away and they turn purple in cold or hot water. I have severe pain in my hands , knees, lower back and elbows. My muscles hurt very bad and they are weak. I wake up with migraines for up to 7 days straight. My question is why is my blood work neg. but my biopsy psitive and i experience all these symptoms and can S.C.L.E. turn into S.L.E?