Addison?s diseaseis a rare endocrine disorder in which the adrenal gland does not produce enough steroid hormones (glucocorticoids and often mineralocorticoids). A problem with your immune system usually causes Addison's disease. The immune system mistakenly attacks your own tissues, damaging your adrenal glands.

Buerger's disease is a rare disease of the arteries and veins in the arms and legs. In Buerger's disease, blood vessels swell and can become blocked with blood clots .This eventually damages or destroys skin tissues and may lead to infection and gangrene. Buerger's disease usually first shows in the hands and feet and may expand to affect larger areas of arms and legs. It is found in smokers and other forms of tobacco users more common in the Middle East and Far East. Buerger's disease usually affects men between ages 20 and 40, though it's becoming more common in women.

Acromegaly is a syndrome that results when the pituitary gland produces excess growth hormone (hGH) after epiphyseal plate closure. Acromegaly most commonly affects adults in middle age and can result in severe disfigurement, serious complicating conditions, and premature death if unchecked.

Acid maltase deficiency is a neuro muscular, autosomal recessive disease metabolic disorder characterized by an excessive accumulation of glycogen within lysosome-derived vacuoles in nearly all types of cells.

Zellweger syndrome is also known as cerebrohepatorenal syndrome is a rare, congenital disorder, characterized by the reduction or absence of peroxisomes in the cells of the liver, kidneys, and brain. It is a type of peroxisomal disorder. Peroxisomal disorders are a group of genetically heterogeneous metabolic diseases that share dysfunction of peroxisomes. Zellweger syndrome is the most severe form of peroxisome biogenesis disorders. Other peroxisome biogenesis disorders are Infantile Refsum disease, neonatal adrenoleukodystrophy and rhizomelic chondrodysplasia.